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Local Immunity Status and Apoptosis Reactions in Endometrium of Women with a History of Non-Developing Pregnancy

In order to estimate the status of local immunity of women with a history of non-developing pregnancy, we conducted a research of cytokine-producing cells (CD4+IFN-γ+, CD4+IL-4+) and apoptosis markers (AnV+/ PI--, AnV+/PI+-, AnV-/PI+-cells) in endometrial biopsy material. In addition to this, we studied the number of activated blood mononuclears expressing CD95+ receptor. The research has shown that the development of chronic inflammation in endometrium is associated with anaerobic dysbiosis of vaginal microbiota coupled with impaired production of intracellular cytokines, a cytokine balance shift towards Th1-dependent immune response at the local level and an increase in production of proinflammatory mediators in blood serum.

A compensatory reaction limiting the number of activated cells in endometrium is expressed in an increased number of apoptosising mononuclears at different stages of cell death. A decrease in the number of cells demonstrating readiness to programmed cell death in peripheral blood indicates that potentially dangerous activated lymphocytes are preserved in circulation at the system level. Defining the polarization index of cytokineproducing cells and the number of endometrial mononuclears expressing Fas-antigen may be used as additional criteria for early detection of endometrial conditions.


Chistyakova GN, Remizova II, Melkozerova OA, Pogorelko DV, Dankova IV and Esareva AV

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