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Abstract

The Frequency of Chromosomal Abnormalities in Individuals with Susceptibility to Abortion and/or Infertility by Cytogenetics Method

Background and Aim: Abnormality karyotype of couples can produce susceptibility to infertility or abortion. Therefore, the first step to study these couples should be determining karyotype by cytogenetic method. In this study assay the prevalence of abnormalities chromosomal these couples from western provinces of Iran.

Method: A cytogenetic study was performed on 200 individuals (124 women (28.1 ± 5) and 76 males (30.7 ± 5) with infertility and/or abortion with age average 30.81 ± 5 using lymphocyte culture and high-resolution G-banding method.

Results: Normal karyotype and various types of chromosomal abnormalities were observed in 138 (69%) and 62 (31%) individuals, respectively. Also, the frequency of translocations, insertions, deletions, inversions and duplications were 40.32% (25), 22.6% (14), 17.74% (11), 9.7% (6) and 9.7% (6) respectively, that the highest frequency was related to changes in transposition or chromosomal displacement with 25 cases (40.3%) In addition, the types of chromosomal abnormalities involving translocations, insertions, deletions, inversions and duplications were detected in 15, 9, 6, 3 and 2 persons, respectively, from 35 patients with RLP and 10, 5, 5, 3 and 4 persons, respectively, of 27 patients with infertility.

Conclusion: This issue can also play a role in the planning of pregnant mother’s health.


Author(s):

Lida Karimi Behbahany, Fatemeh Keshavarzi and Gholamreza Homayounpour



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