Reach Us +1-8507546199
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Status of Metabolic Bone Disease in Pediatric Steroid Resistant Nephrotic Syndrome: Study from North India

Background: Children with steroid resistant nephrotic syndrome (SRNS) are at a greater risk of metabolic bone disease due to biochemical derangements by corticosteroids and immunosuppressant therapy. The present study was undertaken to evaluate the calcium-vitamin D status in children with SRNS.

Method: A cross-sectional case control study was performed to investigate the calcium-vitamin D status in 50 patients of SRNS and 40 healthy controls. Serum levels of 25 hydroxy vitamin D [25(OH) D], calcium, phosphorus, alkaline phosphatase (ALP) and parathyroid hormone (PTH) were estimated. The SRNS patients were further divided into 3 groups according to their Up:Uc ratio: Group A) 16 patients in complete remission, Group B) 14 patients in partial remission and Group C) 20 patients in relapse.

Results: Vitamin D and calcium levels were significantly lower in the SRNS patients (p<0.0001). Lower levels of vitamin D and calcium were found in the relapse phase (p<0.01 and p=0.001). PTH and ALP levels were higher (p<0.05 and p=0.001). Up:Uc ratio with vitamin D and calcium showed a significant negative correlation (p<0.01 and p<0.05) whereas a positive correlation was seen with PTH and ALP ( p<0.05 for both).

Conclusion: There is a clear diminution of serum 25 (OH) D in patients with SRNS which reverts rapidly to normal after cessation of proteinuria which may associate with severe nephrotoxicity. Prophylactic therapy with vitamin D should be routinely advocated in these patients.


Shikha Sharma, Pradeep Kumar Dabla and Manish Kumar

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
Flyer image

Abstracted/Indexed in

  • Index Copernicus
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Directory of Research Journal Indexing (DRJI)
  • Publons
  • Secret Search Engine Labs