The silent killer or essential hypertension, is an important risk factor for cardiovascular disease, it affects 20% to 30% of the population worldwide and will alarmingly rise to 1.5 billion by 2020. Its heritability is around 31 to 68%, besides affecting environmental factors. Comparing to the last years, there have been a substantial progress in the understanding of the Blood pressure and HTN etiology. We provide an overview of the current findings of the GWAS aiming to contribute in the understanding of the pathophysiology of Blood pressure and HTN. From the fact that only a fraction of the phenotypic variability of BP can thus far be explained by the recently discovered common genetic polymorphisms from GWAS, therefore, we tried to highlight the major role of rare and structural variants, epigenetics in the missing heritability of HTN.