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Differential Distribution of GABA and GAT1 in Mouse Epididymis

The present study is to explore the relationship between GABA/GAT1 and mechanism of sperm maturation in epididymis. The distribution of GABA and GAT1 was observed under microscope in different magnifications. Immune labeled GABA and GAT1 at the different regions of epididymis was semi-quantified. Our data illustrated that GABA was significantly higher produced at caput of epididymis than that at corpus or cauda of epididymis. Consistently, the distribution of GAT1 showed similar patterns at the different regions of epididymis. The current data suggested that differential expression of GABA and its transport protein I (GAT1) at the different regions of epididymis may be related to maturation and subsequently the function of sperms. Such information may also contribute to our clinical practice in Andrology.


Lixin Qi, Jiahua Hu, Lihe Guo, Huailiang Feng, Wenping Zhang and Jinfu Zhang

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