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Diclofenac Orodispersible Tablets: Formulation and In Vitro Evaluation

Aim: The aim of the present study is to prepare and evaluate Diclofenac sodium orodispresible tablets by using two super disintegrates, such as croscarmellose sodium (CCS) and sodium starch glycolate (SSG) in different concentrations by using direct compression technique.

Materials and methods: We prepared 8 formulations by using direct compression technique. For this preparation, we have used different excipients along with the Dicofenac sodium drug such as sodium starch glycolate, carboxy methyl cellulose, lactose, mannitol, croscarmellose sodium, micro crystalline cellulose, magnesium stearate and talc. To identify the drug, we have used two methods such as Ultraviolet Spectroscopy and Capillary tube method.

Results: All the formulations are disintegrated within one minute indicating the suitability of the product. Among all the formulations, F1, F5 and F6 showed maximum drug released within 30 minutes compared to other formulations. F1 formulation contains SSG 10%, F5 formulation contains CCS 10% and F6 contains CCS 20%. And F6 formulation gave 100% drug release when compared to F5 formulation which gave 82.3% of drug release within 30 minutes.


CH Kantharao , K Swarna, J Leelakrishna, J Anusha, B Asha and B Bhavani

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